Drug intelligence / Profile preview

[Pt(NH3)2(IBgly)]NO3

Development stage
Preclinical
Modality
Small Molecules
01

Overview

[Pt(NH3)2(IBgly)]NO3 is a **platinum(II) coordination complex** consisting of platinum bound to two ammine (NH3) ligands and one N-isobutylglycine (IBgly) ligand, with nitrate as a counterion. It is structurally related to the class of platinum(II) ammine complexes explored as anticancer agents, modeled after compounds like cisplatin. The IBgly ligand can modulate the compound's physicochemical properties such as solubility, stability, and potentially its biological activity or toxicity profile compared to more widely studied platinum-based drugs. The expected mechanism of action—by analogy with related platinum(II) coordination complexes—involves **binding to DNA, forming intrastrand and interstrand cross-links that interfere with DNA replication and transcription, ultimately leading to cell death**. Primary research indicates [Pt(NH3)2(IBgly)]NO3 is an experimental platinum compound and has been characterized by spectroscopic methods for evaluation as a possible anticancer candidate[4].

02

Targets

DNA

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